The Guyandotte River in West Virginia offers anglers a diverse and rewarding fishing experience across its 166-mile course. Flowing from its headwaters in Wyoming County to its confluence with the Ohio River in Cabell County near Huntington, this scenic river features cool, clear waters in its upper sections and warmer waters downstream. The river runs through rugged Appalachian terrain covered in thick forests, with a landscape peppered with historic coal mining towns and relics of the region's industrial past. The Guyandotte provides varied fishing opportunities throughout the year, with several distinct sections offering different experiences for anglers targeting a wide range of fish species.