Mill Creek flows through Hendricks, Morgan, Owen, and Putnam Counties as a tributary of Big Walnut Creek, offering diverse fishing opportunities across its length. This waterway supports populations of warmwater species that thrive in Indiana's creek systems. The creek's health has shown improvement in recent years, with Index of Biotic Integrity scores placing it in the fair category, indicating moderate ecological quality. The stream features varied habitat including pools, riffles, and areas with structure that attract both resident and migratory fish populations. Mill Creek provides accessible fishing opportunities ranging from wade fishing to fishing from the banks, making it suitable for anglers of different skill levels.