Little River flows through multiple Georgia counties—Columbia, Lincoln, McCormick, McDuffie, Taliaferro, Warren, and Wilkes—before entering South Carolina, eventually joining the Savannah River above J. Strom Thurmond Lake (also known as Clarks Hill Lake). This waterway creates a 23-mile water trail through the upper coastal plain region, passing through the expansive Clarks Hill Wildlife Management Area which covers 15,000 acres. The river's character ranges from flatwater sections suitable for beginners to areas with fallen trees and rocky substrate. Its proximity to Clarks Hill Lake creates exceptional fishing opportunities, particularly where the river transitions into the lake's upper reaches. Steep banks, narrow cuts, and numerous tributaries define much of Little River's character, with diverse habitat including wood cover, clay banks, and deep water channels that concentrate fish populations.