Clarke Falls is a waterfall on the Mersey River in Tasmania's Central Highlands, located in the remote Never Never valley between the Walls of Jerusalem and Cradle Mountain National Parks.

The falls mark the point where the Mersey River drops out of Junction Lake and begins its westward journey through the valley. The falls sit at the upper end of a spectacular series of cascades along the Mersey, with McCoy Falls lying roughly 2.

8 kilometres downstream and Hartnett Falls further beyond. The surrounding landscape combines alpine scenery and rainforest, and the area is accessible via multi-day bushwalking routes including the Never Never track and the Overland Track.