Twelvemile Creek and its East Branch flow through northern Niagara County to their mouths at Lake Ontario, 12 miles east of the Niagara River near the village of Wilson. This 69-square-mile watershed system offers diverse fishing opportunities throughout the year, with the creeks serving as important Lake Ontario tributaries. The streams transition from agricultural landscapes upstream to more protected areas near the mouth, where Wilson-Tuscarora State Park provides a buffer zone. Both branches feature 6.1 miles of public fishing rights easements, making significant portions of these productive waters accessible to anglers. The system's close connection to Lake Ontario creates excellent migratory fisheries, while resident warmwater species add year-round variety.