North River is a flowing stream located in northeastern Missouri that drains approximately 381 square miles across five counties: Knox, Shelby, Monroe, Marion, and Ralls. Originating in Knox County, the river flows southeast for approximately 78 miles before emptying into the Upper Mississippi River at River Mile 321. The watershed lies within two major land resource areas - the Central Mississippi Valley Wooded Slopes in the lower half of the basin and the Central Claypan region in the upper half. The river's character varies throughout its length, with some sections resembling Ozark streams, offering diverse aquatic habitats and excellent fishing opportunities.