Myakka River State Park's boat ramp is located near the concession area with a paved launch surface and nearby trailer parking.

All motorized boats must pay a $4 launch fee at the ranger station, and boats must observe strict minimum speed/no wake regulations; the ramp may close during especially dry periods due to seasonal water level variation.

To access areas south of State Road 72, boaters must obtain a wilderness preserve permit (limited to 30 people per day) and register at the ranger station.