Myakka River State Park's boat ramp is a paved launch facility located near the concession area with nearby trailer parking. Motorized boats must pay a $4 launch fee at the ranger station, and all vessels must observe strict minimum speed/no-wake regulations.

To access areas south of State Road 72, boaters must obtain a wilderness preserve permit (limited to 30 people per day) and register at the ranger station on the day of use.