Otselic River Access in Chenango County provides public fishing access along 22 miles of the river with eight official Public Fishing Rights (PFR) parking areas and numerous unofficial pull-offs along Route 26.

Multiple hand-launch access points are available throughout the region, including locations at Otselic Center, South Otselic, Pitcher, and other hamlets, though there are no on-site amenities so visitors should practice Leave No Trace principles.