The Coldwater River is a stream located in Quitman and Tallahatchie Counties in the Mississippi Delta region. Established as a National Wildlife Refuge in 1991, the river and surrounding refuge play significant roles in supporting migratory birds and other wildlife. The Coldwater River offers anglers opportunities to catch various fish species, particularly catfish varieties that thrive in its waters. With approximately 2,514 acres of protected lands, the river provides both recreational fishing and important habitat for wildlife conservation.