Mill Branch is a tributary of the Buffalo River flowing through Newton and Searcy Counties in Arkansas. As part of the Buffalo National River system, this small tributary contributes to one of Arkansas's premier smallmouth bass fisheries. The creek flows through the Ozark Mountains region, joining the Buffalo River system which is renowned for its cool, clean waters and exceptional water clarity. The tributary shares the Buffalo River's characteristic habitat features including varied substrate composition, rocky structures, and the diverse aquatic life that makes the Buffalo National River watershed a favored destination for anglers seeking both smallmouth bass and panfish in a pristine natural setting.