De Grote Wielen (also written Grutte Wielen) is a nature reserve situated between Leeuwarden and Gytsjerk in Friesland, managed by It Fryske Gea.

The area encompasses open water, reed beds, and polders set within a historically significant peat and clay landscape.

The large pools — including the Groote Wielen, Houtwiel, and Sierdswiel — formed through medieval flooding of the Middelzee and peat drainage from the east. Public access is partial and seasonal.

The walking route through the Binnemiedepolder and Weeshúspolder closes from 15 March to 15 July to protect nesting meadow birds, while the Ryptsjerksterpolder route is only open from 15 June to 1 October.

A viewing mound offers year-round views over the polders. Parking is available along the Kooiweg to the north, Westerdyk to the east, and Groningerstraatweg to the south. The birdwatching hide 't Set is wheelchair accessible.