Río Simpson flows through one of the most spectacular and productive fly fishing landscapes on earth — the Aysén Region of Chilean Patagonia. Running parallel to the Carretera Austral between the regional capital of Coyhaique and Puerto Aysén, the river passes through the Río Simpson National Reserve, a 40,827-hectare protected area established in 1967 and one of the oldest conservation zones in the region. The reserve was created in direct response to the widespread devastation caused by fires, overexploitation, and the resulting floods, landslides, and erosion that threatened both the ecosystem and the only road connecting these communities. Today, the Río Simpson is widely regarded as one of the finest fly fishing rivers in the world — ranked among the top four globally — drawing experienced anglers from across Chile and internationally who come to experience its remarkably prolific trout fishery set against the backdrop of the Patagonian Andes.