Klondike River Campground is a Yukon Government–operated campground situated at Km 20 on the North Klondike Highway, about 20 kilometres south of Dawson City.

Open from May through September, it offers quiet, well-maintained sites alongside picnic tables, fire rings, a cook shelter, outhouses, bear-proof caches, and a playground. At least one wheelchair-accessible campsite and outhouse are available.

A highlight of the campground is a 1. 7-kilometre interpretive trail and boardwalk leading through old-growth forest — land that was never dredged or logged during the Gold Rush — down to the Klondike River itself.

The area supports a rich variety of plant life, and signage interprets local cultural and natural history, including the river's Hän name, Tr'ondëk, which references the hammer rock used to drive salmon weir stakes into the river's mouth.