Lathrop Canyon offers primitive backcountry camping (Airport A-D campsites) accessible via a 12. 2-mile round-trip trail from the Island in the Sky District of Canyonlands National Park, with the final 3. 6 miles descending via 4WD road to the Colorado River.

Permits are required for overnight camping, and the area features historical uranium mines that should be avoided.

Paddlers can access the Colorado River via this route, though the journey involves significant elevation change and is best suited for experienced backcountry users.