Highway 21 Boat Ramp is an unimproved gravel access point on the South Fork Edisto River in Aiken County with a single-lane ramp and approximately 15 parking spaces for vehicles and trailers.

Located near the New Holland Road bridge, it provides a basic but functional launch option for boaters and paddlers accessing this section of the river.

The gravel surface and limited amenities make it best suited for those with experience launching at rustic access points.