Grand Lake St Marys State Park offers multiple fishing access points including an accessible fishing pier at East Bank and an accessible fishing access area at West Bank, making it convenient for anglers of all abilities.

Eight state-operated boat launch ramps provide access to the 13,500-acre lake, with a 300-foot no-wake zone enforced around the 52 miles of shoreline. A valid Ohio fishing license is required for anglers 16 and older.