Hornopirén is a small town in the Palena Province of Chile's Los Lagos Region, situated on the western bank of the Río Cuchildeo where that river empties into the northern reach of Canal Hornopirén.

The Río Cuchildeo originates on the southern slopes of Volcán Hornopirén and flows southward on a short course before reaching the canal, placing the town at a natural gateway between the coastal waterway and the volcanic interior.

The area lies roughly 10 kilometers east of the surrounding hills, with routes leading toward Volcán Hornopirén and Lago Cabrera.

The river itself is classified as a ritrón-type watercourse, characteristic of fast-moving, cold Andean streams, making Hornopirén a practical access point for exploring the rugged terrain of this remote corner of Chilean Patagonia.