The Miramichi River system is made up of several distinct branches and tributaries, each offering its own character and fishing opportunities.

Main Southwest Miramichi River — The main stem of the Southwest Miramichi is widely considered the most productive stretch in the entire system. The lower stretch of the Main Southwest Miramichi, located approximately five miles above the tidal influx, is particularly prized because anglers are consistently fishing over some of the freshest and most active salmon on their upriver migration. This lower section is where many of the premier private pools are concentrated, and it is the heart of the guided salmon fishing experience on the Miramichi.

Northwest Miramichi River — The Northwest Miramichi is recognized by Fisheries and Oceans Canada as the only known and successful spawning ground for striped bass in the southern Gulf of St. Lawrence. This makes it a critical area for both striped bass conservation and management discussions.

Little Southwest Miramichi River and its Branches — The Lower North Branch of the Little Southwest Miramichi, from Rocky Rapids Pool upstream to its source including tributaries, is a designated catch-and-release stretch open year-round. The North Branch Southwest Miramichi River, from 150 metres downstream of the road bridge at Bridge Pool upstream to its source, is open from July 1 through the end of the angling season.

Cains River — A renowned tributary of the Miramichi system, the Cains River is accessible through select outfitters and features both a Lower Cains River Stretch and an Upper Cains River Stretch, both designated as special regulation waters with a four-rod limit. The Cains River is considered one of the most productive and storied salmon tributaries in the watershed.

North Pole Stream — From its confluence with the Little Southwest Miramichi upstream to its source, including the East Branch and West Branch, North Pole Stream is open to angling year-round and features designated special regulation stretches including the Sinclair Stretch and the Palisades Stretch.