Rio Santo Antônio is a significant river in the state of Minas Gerais, Brazil, rising in the Espinhaço Mountains in the district of Santo Antônio do Cruzeiro, within the city of Conceição do Mato Dentro. After a journey of approximately 287 kilometers running eastward, the river pours its waters into the Rio Doce. The river is historically notable as a route used by the bandeirantes during the Brazil Gold Rush, and today it serves as a destination for fishing, gold panning, leisure, and tourism. Its course is defined by a dramatic rocky character, featuring numerous waterfalls — most famously the Tabuleiro Falls, rated in the 2005 edition of the Guia 4 Rodas as the most beautiful waterfall in Brazil, as well as the Bahia Falls. This rugged, scenic terrain makes Rio Santo Antônio one of the more distinctive river systems in the Minas Gerais highlands.