Big Millstream Falls is located in Millstream Falls National Park, approximately 3 km from Ravenshoe — Queensland's highest town — on the Atherton Tablelands.

The falls drop 45 metres (147 feet) over basalt rock into a rugged gorge below and are reputedly the widest single-drop waterfall in Australia. The park also features a smaller companion cascade, Little Millstream Falls.

A short, moderate lookout trail of around 0. 4 miles provides views of the falls and involves roughly 100 feet of elevation gain, typically taking under an hour to complete.

The surrounding national park protects open forest on volcanic terrain and holds cultural and World War II historical significance.