Río Calera flows through the Burruyacu department of Tucumán province in northwestern Argentina, draining into the upper Río Salí basin. This river winds through a region of significant ecological diversity in the foothills and lowlands of Tucumán, contributing its waters to one of the most important river systems in the province. The upper Río Salí basin, of which Río Calera is a part, supports a notable array of native fish species adapted to the varied conditions of this subtropical river system.