Laguna Setúbal, also known as Laguna de Guadalupe, is a freshwater lake situated in the Santa Fe province of Argentina, closely tied to the broader Paraná-Platense drainage system that defines this region's rich aquatic ecology. Nestled near the city of Santa Fe, this lagoon is part of the floodplain wetland complex characteristic of the middle Paraná River corridor, where seasonal flooding and the dynamic interplay between river and lagoon systems create highly productive fishing environments. The lake draws anglers from the surrounding region seeking a diverse array of native South American species in a setting that reflects the biological richness of the Paraná basin.