The Arroyo Pepirí Miní o Yabotí Guazú is a significant river system flowing through the heart of Misiones Province in northeastern Argentina, draining into the Río Uruguay just downstream of the famous Saltos del Moconá. The river originates in the Sierra de Misiones near the locality of Paraíso in the Departamento de Guaraní, and from its confluence with the Arroyo Fortaleza onward, it forms the boundary between the Departamento de Guaraní and the Departamento de General Manuel Belgrano before turning southward to meet the Río Uruguay. The watershed is one of the most extensive in the province and sits within one of Argentina's best-preserved natural ecosystems, protected by the Reserva de la Biósfera Yabotí, the Parque Provincial Moconá, and the Parque Provincial Esmeralda. The surrounding landscape is dominated by dense Paranaense (Atlantic Forest) jungle, with steep slopes characterizing much of the terrain and 95% of the reserve covered by laurel and guatambú forest, with emergent trees reaching up to 30 meters in height. This is genuinely wild, remote fishing in one of South America's most ecologically intact river systems.